Mouse Notch3 intracellular domain, NICD3, induces transcript...

created [InstanceEdit:9016906] Orlic-Milacic, Marija, 2017-08-16
dbId 9016904
displayName Mouse Notch3 intracellular domain, NICD3, induces transcript...
modified [InstanceEdit:9017142] Orlic-Milacic, Marija, 2017-08-16
schemaClass Summation
text Mouse Notch3 intracellular domain, NICD3, induces transcription from the Ptcra gene promoter, encoding pre-TCR-alpha, in a dose-dependent manner. The Ptcra promoter contains several Rbpj-binding sites and NICD3-mediated induction of Ptcra is Rbpj and Maml dependent (Talora et al. 2003, Bellavia et al. 2007). Binding of Ik1, a splicing isoform of Ikaros (Ikzf1) to the Ptcra promoter competes with Rbpj binding and results in repression of Ptcra transcription (Bellavia et al. 2007).
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