Reactome | Jak2 transphosphorylates and is activated in response to Erythropoietin

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Jak2 transphosphorylates and is activated in response to Erythropoietin Show undefined attributes

authored	[InstanceEdit:9006330] May, Bruce, 2017-04-22
catalystActivity	[CatalystActivity:9006331] protein tyrosine kinase activity of Epo:Epor:Jak2:Lyn:Irs2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643673] protein tyrosine kinase activity of Epo:Epor:Jak2:Lyn:Irs2 [plasma membrane] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9006333] May, Bruce, 2017-05-13
dbId	9006329
displayName	Jak2 transphosphorylates and is activated in response to Erythropoietin
edited	[InstanceEdit:9006330] May, Bruce, 2017-04-22
input	22 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-9006304] Epo:Epor:Jak2:Lyn:Irs2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208315] JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin [LiteratureReference:9006205] Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity [LiteratureReference:9006199] Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function [LiteratureReference:9006156] Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail [LiteratureReference:9006230] Requirement for JAK2 in erythropoietin-induced signalling pathways [LiteratureReference:9006226] Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction [LiteratureReference:9006190] Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo [LiteratureReference:9006246] In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130 [LiteratureReference:9027081] Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells [LiteratureReference:873856] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop [LiteratureReference:9030302] A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Jak2 transphosphorylates and is activated in response to Erythropoietin
orthologousEvent	[Reaction:R-HSA-9006332] JAK2 transphosphorylates and is activated in response to Erythropoietin - Homo sapiens
output	23 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-9006307] Epo:Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane]
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9006329
summation	[Summation:9030324] Upon binding Epo, the Epor dimer changes conformation result...