Reactome | Epo binds Epor:Jak2:Lyn:Irs2

Schema > Reaction > Entries

Epo binds Epor:Jak2:Lyn:Irs2 Show undefined attributes

authored	[InstanceEdit:9006330] May, Bruce, 2017-04-22
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9006333] May, Bruce, 2017-05-13
dbId	9006326
displayName	Epo binds Epor:Jak2:Lyn:Irs2
edited	[InstanceEdit:9006330] May, Bruce, 2017-04-22
input	[EntityWithAccessionedSequence:R-MMU-9006278] Epo [extracellular region] [Complex:R-MMU-9006302] Epor:Jak2:Lyn:Irs2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1364060] Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation [LiteratureReference:9006198] Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain [LiteratureReference:9006228] Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function [LiteratureReference:9006193] Expression cloning of the murine erythropoietin receptor [LiteratureReference:9006152] Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer [LiteratureReference:9006199] Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function [LiteratureReference:9027182] Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway [LiteratureReference:9027418] Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells [LiteratureReference:9027143] Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation [LiteratureReference:9029059] Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn [LiteratureReference:9030310] Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains [LiteratureReference:208315] JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin [LiteratureReference:9006226] Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Epo binds Epor:Jak2:Lyn:Irs2
orthologousEvent	[Reaction:R-HSA-9006325] EPO binds EPOR:JAK2:LYN:IRS2 - Homo sapiens
output	[Complex:R-MMU-9006304] Epo:Epor:Jak2:Lyn:Irs2 [plasma membrane]
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9006326
summation	[Summation:9030333] Extracellular Erythropoietin (Epo) binds the Epo receptor (E...

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