Extracellular Erythropoietin (Epo) binds the Epo receptor (E...

created [InstanceEdit:9030315] May, Bruce, 2017-11-27
dbId 9030333
displayName Extracellular Erythropoietin (Epo) binds the Epo receptor (E...
schemaClass Summation
text Extracellular Erythropoietin (Epo) binds the Epo receptor (Epor) located in the plasma membrane of the target cell (D'Andrea et al. 1989). Epor is a dimer (Livnah et al. 1999, Constantinescu et al. 2001) that appears to be preassociated with downstream signaling proteins Jak2 (Witthuhn et al. 1993, Miura et al. 1994, Sawyer and Penta 1996, Pelletier et al. 2006) and Lyn (Tilbrook et al. 1997, Chin et al. 1998, Tilbrook et al. 2001) and the scaffold protein Irs2 (Verdier et al. 1997). Binding of Epo to Epor causes a change in the conformation of the dimer which activates Jak2 (Witthuhn et al. 1993, Seubert et al. 2003, Kubatzky et al. 2005, Lu et al. 2005, Lu et al. 2006).
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