Reactome | Regulation of RUNX3 expression and activity

Schema > Pathway > Entries

Regulation of RUNX3 expression and activity Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101515
displayName	Regulation of RUNX3 expression and activity
eventOf	[Pathway:R-MMU-8878159] Transcriptional regulation by RUNX3 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-8937814] RUNX3 translocates to the nucleus - Mus musculus [Reaction:R-MMU-8937792] RUNX3 binds SRC - Mus musculus [Reaction:R-MMU-8937807] SRC phosphorylates RUNX3 - Mus musculus [Reaction:R-MMU-8865454] CBFB binds RUNX3 - Mus musculus [Reaction:R-MMU-8952371] MDM2 binds RUNX3 - Mus musculus [Reaction:R-MMU-8952382] MDM2 polyubiquitinates RUNX3 - Mus musculus [BlackBoxEvent:R-MMU-8952399] Polyubiquitinated RUNX3 translocates to the cytosol - Mus musculus [BlackBoxEvent:R-MMU-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Mus musculus [Reaction:R-MMU-8952419] SMURFs ubiquitinate RUNX3 - Mus musculus
inferredFrom	[Pathway:R-HSA-8941858] Regulation of RUNX3 expression and activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of RUNX3 expression and activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-8941858
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8878159] Transcriptional regulation by RUNX3
(inferredTo)	[Pathway:R-HSA-8941858] Regulation of RUNX3 expression and activity

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