Reactome | PXLP-K405-GAD1 decarboxylates L-Glu to form GABA

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PXLP-K405-GAD1 decarboxylates L-Glu to form GABA Show undefined attributes

catalystActivity	[CatalystActivity:10021236] glutamate decarboxylase activity of PXLP-K405-GAD1 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10021238
displayName	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA
eventOf	[Pathway:R-MMU-888568] GABA synthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-888572] PXLP-K405-GAD1 decarboxylates L-Glu to form GABA - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA Synthesis of GABA by GAD1
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-352011] GABA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-888572
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-888568] GABA synthesis
(inferredTo)	[Reaction:R-HSA-888572] PXLP-K405-GAD1 decarboxylates L-Glu to form GABA

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