Reactome | Recruitment of AP-2 complex and clathrin

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Recruitment of AP-2 complex and clathrin Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10076952
displayName	Recruitment of AP-2 complex and clathrin
eventOf	[Pathway:R-MMU-8856828] Clathrin-mediated endocytosis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Mus musculus [Reaction:R-MMU-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Mus musculus
inferredFrom	[Reaction:R-HSA-8856808] Recruitment of AP-2 complex and clathrin - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-8854795] AAK1 [cytosol] [Complex:R-MMU-167712] AP-2 Complex [cytosol] [Complex:R-MMU-8856809] clathrin triskelion [cytosol] [CandidateSet:R-MMU-8863469] NECAPs [cytosol] [Complex:R-MMU-8862276] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment of AP-2 complex and clathrin
output	[Complex:R-MMU-8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
regulatedBy	[PositiveRegulation:10076953] Positive regulation by 'ARFGAP1:ARF6:GTP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8856808
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-MMU-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-MMU-8856813] AAK1 phosphorylates AP-2 mu subunit at T156
(inferredTo)	[Reaction:R-HSA-8856808] Recruitment of AP-2 complex and clathrin