Reactome | Thrombin, ELANE cleave C5

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10076227] serine-type endopeptidase activity of Activated thrombin, (ELANE) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10076229
displayName	Thrombin, ELANE cleave C5
eventOf	[Pathway:R-MMU-977606] Regulation of Complement cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8852716] Thrombin, ELANE cleave C5 - Homo sapiens
input	[Complex:R-MMU-173676] C5 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Thrombin, ELANE cleave C5
output	[EntityWithAccessionedSequence:R-MMU-8852711] C5 [extracellular region] [Complex:R-MMU-8852717] C5bT [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8852716
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-977606] Regulation of Complement cascade
(inferredTo)	[Reaction:R-HSA-8852716] Thrombin, ELANE cleave C5

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