Reactome | Thrombin, ELANE cleave C5

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Thrombin, ELANE cleave C5 Show undefined attributes

authored	[InstanceEdit:8851433] Jupe, Steve, 2016-01-06
catalystActivity	[CatalystActivity:8852732] serine-type endopeptidase activity of Activated thrombin, (ELANE) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:8852714] Jupe, Steve, 2016-01-20
dbId	8852716
displayName	Thrombin, ELANE cleave C5
edited	[InstanceEdit:8959925] Jupe, Steve, 2017-02-01
eventOf	[Pathway:R-HSA-977606] Regulation of Complement cascade - Homo sapiens
input	[Complex:R-HSA-173676] C5 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8852715] Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Thrombin, ELANE cleave C5
orthologousEvent	[Reaction:R-GGA-8852716] Thrombin, ELANE cleave C5 - Gallus gallus [Reaction:R-DRE-8852716] Thrombin, ELANE cleave C5 - Danio rerio [Reaction:R-SSC-8852716] Thrombin, ELANE cleave C5 - Sus scrofa [Reaction:R-BTA-8852716] Thrombin, ELANE cleave C5 - Bos taurus [Reaction:R-CFA-8852716] Thrombin, ELANE cleave C5 - Canis familiaris [Reaction:R-RNO-8852716] Thrombin, ELANE cleave C5 - Rattus norvegicus [Reaction:R-MMU-8852716] Thrombin, ELANE cleave C5 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8852711] C5aT [extracellular region] [Complex:R-HSA-8852717] C5bT [extracellular region]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959927] Bulla, Roberta, 2017-02-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8852716
summation	[Summation:8852708] Thrombin, coagulation factors XIa, Xa, IXa and plasmin (Amar...

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(hasEvent)

[Pathway:R-HSA-977606] Regulation of Complement cascade

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