Reactome | PTK6 Activates STAT3

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PTK6 Activates STAT3 Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101441
displayName	PTK6 Activates STAT3
eventOf	[Pathway:R-MMU-8848021] Signaling by PTK6 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24796] positive regulation of receptor signaling pathway via JAK-STAT
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-8848023] Activated PTK6 binds STAP2 - Mus musculus [Reaction:R-MMU-8848077] PTK6 phosphorylates STAP2 - Mus musculus [Reaction:R-MMU-8848087] STAP2 recruits STAT3 to PTK6 - Mus musculus [Reaction:R-MMU-8848124] PTK6 phosphorylates STAT3 - Mus musculus [Reaction:R-MMU-8848110] SOCS3 binds activated PTK6 - Mus musculus
inferredFrom	[Pathway:R-HSA-8849474] PTK6 Activates STAT3 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PTK6 Activates STAT3
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-8849474
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-8849474] PTK6 Activates STAT3

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