Reactome | Regeneration of active (reduced) Thioredoxin

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Regeneration of active (reduced) Thioredoxin Show undefined attributes

catalystActivity	[CatalystActivity:9988241] thioredoxin-disulfide reductase (NADPH) activity of TNXRD1:FAD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9988243
displayName	Regeneration of active (reduced) Thioredoxin
eventOf	[Pathway:R-MMU-5628897] TP53 Regulates Metabolic Genes - Mus musculus [Pathway:R-MMU-3299685] Detoxification of Reactive Oxygen Species - Mus musculus [Pathway:R-MMU-499943] Interconversion of nucleotide di- and triphosphates - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Mus musculus [Reaction:R-MMU-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Mus musculus [Reaction:R-MMU-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN - Mus musculus [Reaction:R-MMU-5631885] PRDX1 overoxidizes - Mus musculus [Reaction:R-MMU-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Mus musculus
inferredFrom	[Reaction:R-HSA-73646] Regeneration of active (reduced) Thioredoxin - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [EntityWithAccessionedSequence:R-MMU-73668] Txn [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Regeneration of active (reduced) Thioredoxin (thioredoxin)-disulfide + NADPH + H(+) => (thioredoxin)-dithiol + NADP(+)
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [EntityWithAccessionedSequence:R-MMU-66000] Txn [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-73646
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Reaction:R-MMU-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Reaction:R-MMU-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN [Reaction:R-MMU-5631885] PRDX1 overoxidizes [Reaction:R-MMU-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
(hasEvent)	[Pathway:R-MMU-499943] Interconversion of nucleotide di- and triphosphates [Pathway:R-MMU-5628897] TP53 Regulates Metabolic Genes [Pathway:R-MMU-3299685] Detoxification of Reactive Oxygen Species
(inferredTo)	[Reaction:R-HSA-73646] Regeneration of active (reduced) Thioredoxin