Reactome | RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)

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RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) Show undefined attributes

catalystActivity	[CatalystActivity:9992195] ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor of RNR (M1M2B) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9992197
displayName	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
eventOf	[Pathway:R-MMU-499943] Interconversion of nucleotide di- and triphosphates - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens
input	[SimpleEntity:R-ALL-8866401] NDP(3-) [cytosol] [EntityWithAccessionedSequence:R-MMU-66000] Txn [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) a ribonucleoside 5'-diphosphate + (thioredoxin)-dithiol => a 2'-deoxyribonucleoside 5'-diphosphate + (thioredoxin)-disulfide + H2O NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
output	[SimpleEntity:R-ALL-8866399] dNDP(3-) [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-MMU-73668] Txn [cytosol]
precedingEvent	[Reaction:R-MMU-73646] Regeneration of active (reduced) Thioredoxin - Mus musculus
regulatedBy	[NegativeRegulation:R-HSA-111772] Negative regulation by 'dATP [cytosol]' [PositiveRegulation:R-HSA-8866468] Positive regulation by 'ATP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-111804
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-499943] Interconversion of nucleotide di- and triphosphates
(inferredTo)	[Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)

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