Reactome | TNFAIP3 (A20) deubiquitinates RIP2

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TNFAIP3 (A20) deubiquitinates RIP2 Show undefined attributes

catalystActivity	[CatalystActivity:10020622] K63-linked deubiquitinase activity of TNFAIP3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10020624
displayName	TNFAIP3 (A20) deubiquitinates RIP2
eventOf	[Pathway:R-MMU-5689896] Ovarian tumor domain proteases - Mus musculus [Pathway:R-MMU-168638] NOD1/2 Signaling Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Homo sapiens
input	[Complex:R-MMU-706480] PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TNFAIP3 (A20) deubiquitinates RIP2
output	6 × [Polymer:R-MMU-450152] K63polyUb [cytosol] [Complex:R-MMU-688994] PAMP:NOD oligomer:RIP2:NEMO [cytosol]
precedingEvent	[Reaction:R-MMU-688137] RIP2 is K63 polyubiquitinated - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-688136
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5689896] Ovarian tumor domain proteases [Pathway:R-MMU-168638] NOD1/2 Signaling Pathway
(inferredTo)	[Reaction:R-HSA-688136] TNFAIP3 (A20) deubiquitinates RIP2

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