Reactome | NOD1/2 Signaling Pathway

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NOD1/2 Signaling Pathway Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099351
displayName	NOD1/2 Signaling Pathway
eventOf	[Pathway:R-MMU-168643] Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1458671] nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-168400] iE-DAP elicits a NOD1 response - Mus musculus [Reaction:R-MMU-168412] MDP elicits a NOD2 response - Mus musculus [Reaction:R-MMU-622310] Activated NOD1 oligomerizes - Mus musculus [Reaction:R-MMU-708349] Activated NOD2 oligomerizes - Mus musculus [Reaction:R-MMU-168405] Activated NOD oligomer recruites RIP2 (RICK) - Mus musculus [Reaction:R-MMU-622415] RIP2 binds NEMO - Mus musculus [Reaction:R-MMU-741386] RIP2 induces K63-linked ubiquitination of NEMO - Mus musculus [Reaction:R-MMU-741411] CYLD deubiquitinates NEMO - Mus musculus [Reaction:R-MMU-688137] RIP2 is K63 polyubiquitinated - Mus musculus [Reaction:R-MMU-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Mus musculus [Reaction:R-MMU-688985] K63 polyubiquitinated RIP2 associates with the TAK1 complex - Mus musculus [BlackBoxEvent:R-MMU-706479] TAK1 is activated - Mus musculus [Reaction:R-MMU-727819] TAK1 phosphorylates MKK6 - Mus musculus [Reaction:R-MMU-622420] NOD1 induced apoptosis is mediated by RIP2 and CARD8 - Mus musculus [Reaction:R-MMU-1247960] Activation of p38 MAPK - Mus musculus [Reaction:R-MMU-9676160] AAMP binds NOD2 - Mus musculus
inferredFrom	[Pathway:R-HSA-168638] NOD1/2 Signaling Pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NOD1/2 Signaling Pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-168638
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-168643] Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
(inferredTo)	[Pathway:R-HSA-168638] NOD1/2 Signaling Pathway

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