Reactome | Sos1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

Sos1 [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-MMU-9009718] SOS1, SOS2 [cytosol] - Mus musculus [CandidateSet:R-MMU-9013168] RAC1 GEFs [cytosol] - Mus musculus
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-354168] GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] - Mus musculus [Complex:R-MMU-983692] BLNK:GRB2:SOS1:CIN85 [cytosol] - Mus musculus
consumedByEvent	[Reaction:R-MMU-354165] Interaction of SOS with GRB2 bound to FADK1 - Mus musculus [Reaction:R-MMU-9607301] Active FLT3:GRB2 binds SOS1 - Mus musculus [Reaction:R-MMU-392053] SOS binds Grb2 bound to pFAK:NCAM1 - Mus musculus [Reaction:R-MMU-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Mus musculus [Reaction:R-MMU-109813] GRB2-1 binds SOS1 - Mus musculus [Reaction:R-MMU-8851859] Activated MET binds RANBP9 and SOS1 - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9989221
displayName	Sos1 [cytosol]
endCoordinate	1333
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-64847] SOS1 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-MMU-194849] GEFs [cytosol] - Mus musculus
name	Sos1 SOS1 Q62245
referenceEntity	[ReferenceGeneProduct:uniprot:Q62245] UniProt:Q62245 Sos1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-64847
startCoordinate	1

Referrals

(hasCandidate)	[CandidateSet:R-MMU-9013168] RAC1 GEFs [cytosol] [CandidateSet:R-MMU-9009718] SOS1, SOS2 [cytosol]
(input)	[Reaction:R-MMU-354165] Interaction of SOS with GRB2 bound to FADK1 [Reaction:R-MMU-9607301] Active FLT3:GRB2 binds SOS1 [Reaction:R-MMU-392053] SOS binds Grb2 bound to pFAK:NCAM1 [Reaction:R-MMU-8851859] Activated MET binds RANBP9 and SOS1 [Reaction:R-MMU-210974] Interaction of SOS-1 to Tie2 bound Grb2 [Reaction:R-MMU-109813] GRB2-1 binds SOS1
(hasComponent)	[Complex:R-MMU-354168] GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] [Complex:R-MMU-983692] BLNK:GRB2:SOS1:CIN85 [cytosol] [Complex:R-MMU-392044] pFAK:Grb2:Sos [cytosol] [Complex:R-MMU-210970] SOS-1 bound to Tie2:Grb2 [plasma membrane] [Complex:R-MMU-9607300] Active FLT3:GRB2:SOS1 [plasma membrane] [Complex:R-MMU-8851860] HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] [Complex:R-MMU-109797] GRB2-1:SOS1 [cytosol]
(activeUnit)	[CatalystActivity:10030582] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-KIT complex [plasma membrane] [CatalystActivity:10006640] guanyl-nucleotide exchange factor activity of SOS-1 bound to Tie2:Grb2 [plasma membrane] [CatalystActivity:10000210] guanyl-nucleotide exchange factor activity of PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] [CatalystActivity:10044803] guanyl-nucleotide exchange factor activity of p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] [CatalystActivity:10013481] guanyl-nucleotide exchange factor activity of Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] [CatalystActivity:9999807] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [CatalystActivity:9999826] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] [CatalystActivity:10087720] guanyl-nucleotide exchange factor activity of Active FLT3:GRB2:SOS1 [plasma membrane] [CatalystActivity:10075850] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]
(hasMember)	[CandidateSet:R-MMU-194849] GEFs [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-64847] SOS1 [cytosol]

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