Reactome | ACSF3 ligates CoA-SH to VLCFA

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ACSF3 ligates CoA-SH to VLCFA Show undefined attributes

catalystActivity	[CatalystActivity:10064028] very long-chain fatty acid-CoA ligase activity of ACSF3 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10064030
displayName	ACSF3 ligates CoA-SH to VLCFA
eventOf	[Pathway:R-MMU-75876] Synthesis of very long-chain fatty acyl-CoAs - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5696007] ACSF3 ligates CoA-SH to VLCFA - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-5696008] VLCFA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ACSF3 ligates CoA-SH to VLCFA a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
output	[SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix] [SimpleEntity:R-ALL-5696003] VLCFA-CoA [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5696007
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-75876] Synthesis of very long-chain fatty acyl-CoAs
(inferredTo)	[Reaction:R-HSA-5696007] ACSF3 ligates CoA-SH to VLCFA

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