Reactome | HERC2 facilitates UBE2N:UBE2V2 binding to RNF8

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HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10060415
displayName	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
eventOf	[Pathway:R-MMU-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5682863] RNF168 binds DNA DSBs - Mus musculus
inferredFrom	[Reaction:R-HSA-5682629] HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 - Homo sapiens
input	[Complex:R-MMU-5682609] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] [Complex:R-MMU-5682542] UBE2N:UBE2V2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
output	[Complex:R-MMU-5682623] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5682629
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-MMU-5682863] RNF168 binds DNA DSBs
(inferredTo)	[Reaction:R-HSA-5682629] HERC2 facilitates UBE2N:UBE2V2 binding to RNF8