Reactome | PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs

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PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs Show undefined attributes

catalystActivity	[CatalystActivity:10060409] SUMO transferase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10060411
displayName	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
eventOf	[Pathway:R-MMU-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5682629] HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 - Mus musculus
inferredFrom	[Reaction:R-HSA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs - Homo sapiens
input	[Complex:R-MMU-5682599] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] [Complex:R-MMU-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
output	[Complex:R-MMU-5682609] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-912483] Ube2i [nucleoplasm]
precedingEvent	[Reaction:R-MMU-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Mus musculus [Reaction:R-MMU-5682598] ATM phosphorylates HERC2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5682607
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-MMU-5682629] HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
(inferredTo)	[Reaction:R-HSA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs