Reactome | DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-MMU-5684095] DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] - Mus musculus [Complex:R-MMU-5684094] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] - Mus musculus
consumedByEvent	[Reaction:R-MMU-5693602] ATM recognizes H2AFX-Nucleosomes - Mus musculus [Reaction:R-MMU-5684081] MRN complex binds CDK2 and RBBP8 - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9985914
displayName	DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
hasComponent	[Complex:R-MMU-5682175] DNA DSBs:p-MRN [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-9735494] Kat5 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5693527] phospho-Atm [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] - Homo sapiens
maxDepth	4
name	DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5
producedByEvent	[Reaction:R-MMU-5684071] RNF4 ubiquitinates MDC1 - Mus musculus [Reaction:R-MMU-5693598] ATM phosphorylates NBN - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-5682162
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-MMU-5684081] MRN complex binds CDK2 and RBBP8 [Reaction:R-MMU-5693602] ATM recognizes H2AFX-Nucleosomes
(hasComponent)	[Complex:R-MMU-5684094] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] [Complex:R-MMU-5684095] DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-MMU-5693563] DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] [Complex:R-MMU-5683952] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] [Complex:R-MMU-5682180] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] [Complex:R-MMU-5682977] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] [Complex:R-MMU-5682995] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] [Complex:R-MMU-5684135] DNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-MMU-5684107] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complex [nucleoplasm]
(inferredTo)	[Complex:R-HSA-5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
(output)	[Reaction:R-MMU-5693598] ATM phosphorylates NBN [Reaction:R-MMU-5684071] RNF4 ubiquitinates MDC1

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