Reactome | PI-3K cascade:FGFR1

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PI-3K cascade:FGFR1 Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099505
displayName	PI-3K cascade:FGFR1
eventOf	[Pathway:R-MMU-5654687] Downstream signaling of activated FGFR1 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Mus musculus [Reaction:R-MMU-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 - Mus musculus [Reaction:R-MMU-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Mus musculus [Reaction:R-MMU-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-5654594] Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Mus musculus [Reaction:R-MMU-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Mus musculus [Reaction:R-MMU-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus
inferredFrom	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PI-3K cascade:FGFR1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5654689
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5654687] Downstream signaling of activated FGFR1
(inferredTo)	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1

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