Reactome | Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1

Schema > Reaction > Entries

Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10058120
displayName	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
eventOf	[Pathway:R-MMU-5654689] PI-3K cascade:FGFR1 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Mus musculus
inferredFrom	[Reaction:R-HSA-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
input	[Complex:R-MMU-5654200] Activated FGFR1:p-FRS2 [plasma membrane] [Complex:R-MMU-179864] GRB2:GAB1:PIK3R1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
output	[Complex:R-MMU-5654186] Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-5654575] Activated FGFR1 phosphorylates FRS2 - Mus musculus [Reaction:R-MMU-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5654592
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5654689] PI-3K cascade:FGFR1
(precedingEvent)	[Reaction:R-MMU-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
(inferredTo)	[Reaction:R-HSA-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1

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