Reactome | CBL ubiquitinates FRS2 and FGFR4

Schema > Reaction > Entries

CBL ubiquitinates FRS2 and FGFR4 Show undefined attributes

catalystActivity	[CatalystActivity:10058275] ubiquitin protein ligase activity of Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10058277
displayName	CBL ubiquitinates FRS2 and FGFR4
eventOf	[Pathway:R-MMU-5654733] Negative regulation of FGFR4 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5654684] CBL ubiquitinates FRS2 and FGFR4 - Homo sapiens
input	[Complex:R-MMU-5654335] Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] [DefinedSet:R-MMU-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL ubiquitinates FRS2 and FGFR4
output	[Complex:R-MMU-5654363] Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5654684
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5654733] Negative regulation of FGFR4 signaling
(inferredTo)	[Reaction:R-HSA-5654684] CBL ubiquitinates FRS2 and FGFR4

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