Reactome | RHO GTPases activate IQGAPs

Schema > Pathway > Entries

RHO GTPases activate IQGAPs Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101201
displayName	RHO GTPases activate IQGAPs
eventOf	[Pathway:R-MMU-195258] RHO GTPase Effectors - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Mus musculus [Reaction:R-MMU-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Mus musculus [Reaction:R-MMU-5626549] IQGAPs bind CALM1 - Mus musculus [Reaction:R-MMU-5672304] IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 - Mus musculus [Reaction:R-MMU-5672329] IQGAP1 binds CLIP1 and microtubules - Mus musculus
inferredFrom	[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases activate IQGAPs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5626467
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-MMU-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs

© 2026 Reactome

Cite Us!