Reactome | K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta

Schema > Reaction > Entries

K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta Show undefined attributes

catalystActivity	[CatalystActivity:10055514] protein serine/threonine kinase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10055516
displayName	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
eventOf	[Pathway:R-MMU-5607764] CLEC7A (Dectin-1) signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-202534] Ubiquitination of NEMO by TRAF6 - Mus musculus
inferredFrom	[Reaction:R-HSA-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-168113] CHUK:IKBKB:IKBKG [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
precedingEvent	[Reaction:R-MMU-5607732] K63polyUb-TAK1 autophosphorylates - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5607742
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5607764] CLEC7A (Dectin-1) signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-202534] Ubiquitination of NEMO by TRAF6
(inferredTo)	[Reaction:R-HSA-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta

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