Reactome | K63polyUb-TAK1 autophosphorylates

Schema > Reaction > Entries

K63polyUb-TAK1 autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10055479] protein serine/threonine kinase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10055481
displayName	K63polyUb-TAK1 autophosphorylates
eventOf	[Pathway:R-MMU-5607764] CLEC7A (Dectin-1) signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta - Mus musculus
inferredFrom	[Reaction:R-HSA-5607732] K63polyUb-TAK1 autophosphorylates - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-5607695] p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	K63polyUb-TAK1 autophosphorylates
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-5607673] p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-MMU-5607757] K63polyUb-TRAF6 ubiquitinates TAK1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5607732
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5607764] CLEC7A (Dectin-1) signaling
(precedingEvent)	[Reaction:R-MMU-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
(inferredTo)	[Reaction:R-HSA-5607732] K63polyUb-TAK1 autophosphorylates