Reactome | Complexed Piwil2 binds pre-piRNA

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Complexed Piwil2 binds pre-piRNA Show undefined attributes

authored	[InstanceEdit:5603160] May, Bruce, 2014-06-29
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5605294] May, Bruce, 2014-07-05
dbId	5605279
displayName	Complexed Piwil2 binds pre-piRNA
edited	[InstanceEdit:5603160] May, Bruce, 2014-06-29
followingEvent	[BlackBoxEvent:R-MMU-5605205] Unknown nuclease cleaves pre-piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:pre-piRNA:Tdrd1:Tdrd12 - Mus musculus
input	[Complex:R-MMU-5605323] 6xMeR-Piwil2:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 [cytosol] [GenomeEncodedEntity:R-MMU-5605348] pre-piRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5605372] A novel class of small RNAs bind to MILI protein in mouse testes [LiteratureReference:5605269] Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells [LiteratureReference:5605232] Cytoplasmic compartmentalization of the fetal piRNA pathway in mice [LiteratureReference:5606240] GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline [LiteratureReference:5606223] Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile [LiteratureReference:5607564] MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs [LiteratureReference:5605313] Mili, a mammalian member of piwi family gene, is essential for spermatogenesis [LiteratureReference:5607559] Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway [LiteratureReference:5605327] Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members [LiteratureReference:5605290] The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors [LiteratureReference:5607992] Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Complexed Piwil2 binds pre-piRNA
orthologousEvent	[Reaction:R-HSA-5603062] Complexed PIWIL2 binds pre-piRNA - Homo sapiens
output	[Complex:R-MMU-5605251] 6xMeR-Piwil2:pre-piRNA:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 [cytosol]
precedingEvent	[Reaction:R-MMU-5605262] Pld6 dimer cleaves primary piRNA transcript to pre-piRNA - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5629251] Saito, Kuniaki, 2014-10-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5605279
summation	[Summation:5615688] After cleavage by Pld6 at the 5' end, the pre-piRNA is bound...

Referrals

(precedingEvent)

[BlackBoxEvent:R-MMU-5605205] Unknown nuclease cleaves pre-piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:pre-piRNA:Tdrd1:Tdrd12

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