Reactome | PKC autophosphorylates

Schema > Reaction > Entries

PKC autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10052817] diacylglycerol-dependent serine/threonine kinase activity of p-PKCA,p-PKCB,p-PKCZ,p-PKCD [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10052819
displayName	PKC autophosphorylates
eventOf	[Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5223304] DAG and Ca+2 bind to PKC and tether it to membrane - Mus musculus [Reaction:R-MMU-5218813] DAG and Ca+2 bind to PKC and tether it to membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-5218805] PKC autophosphorylates - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-MMU-5218754] p-PKCA,p-PKCB,p-PKCZ,p-PKCD [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PKC autophosphorylates
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-MMU-5218758] p-PKC [cytosol]
precedingEvent	[Reaction:R-MMU-5218821] PDK1 phosphorylates PKC - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5218805
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation
(precedingEvent)	[Reaction:R-MMU-5223304] DAG and Ca+2 bind to PKC and tether it to membrane [Reaction:R-MMU-5218813] DAG and Ca+2 bind to PKC and tether it to membrane
(inferredTo)	[Reaction:R-HSA-5218805] PKC autophosphorylates