Reactome | p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis

Schema > Reaction > Entries

p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10051824
displayName	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis
eventOf	[Pathway:R-MMU-5099900] WNT5A-dependent internalization of FZD4 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-5138459] WNT5A:FZD4 is endocytosed - Mus musculus
inferredFrom	[Reaction:R-HSA-5138433] p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-416464] Arrb2 [cytosol] [Complex:R-MMU-5138434] clathrin:AP-2 [plasma membrane] [Complex:R-MMU-5138442] WNT5A:FZD4:p-DVL2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis
output	[Complex:R-MMU-5138437] WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane]
precedingEvent	[Reaction:R-MMU-5138432] DVL2 is phosphorylated by PKC - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5138433
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5099900] WNT5A-dependent internalization of FZD4
(precedingEvent)	[BlackBoxEvent:R-MMU-5138459] WNT5A:FZD4 is endocytosed
(inferredTo)	[Reaction:R-HSA-5138433] p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis

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