Reactome | Dnmt3a [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-MMU-9727443] nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd1:Dnmt3a:Dnmt3l [nucleoplasm] - Mus musculus
consumedByEvent	[Reaction:R-MMU-4655387] Cbx4 (Pc2) Sumoylates Dnmt3a with Sumo1 - Mus musculus [Reaction:R-MMU-9727502] Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex - Mus musculus
created	[InstanceEdit:4655376] May, B, 2013-10-03
dbId	4655420
displayName	Dnmt3a [nucleoplasm]
endCoordinate	908
inDisease	false
maxDepth	1
name	Dnmt3a DNA DNM3A_MOUSE
referenceEntity	[ReferenceGeneProduct:uniprot:O88508] UniProt:O88508 Dnmt3a
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-4655420
startCoordinate	1

(input)	[Reaction:R-MMU-4655387] Cbx4 (Pc2) Sumoylates Dnmt3a with Sumo1 [Reaction:R-MMU-9727502] Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex
(hasComponent)	[Complex:R-MMU-9727443] nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd1:Dnmt3a:Dnmt3l [nucleoplasm] [Complex:R-MMU-5334141] Dnmt3a:Dnmt3l [nucleoplasm]
(activeUnit)	[CatalystActivity:5336214] DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates of Dnmt3a:Dnmt3l:Chromatin [nucleoplasm]
(requiredInputComponent)	[Reaction:R-MMU-9817463] Tet3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3 dimethylated on lysine-9

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