Reactome | Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion

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Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion Show undefined attributes

catalystActivity	[CatalystActivity:10016439] 3'-5'-RNA exonuclease activity of Exosome:SKI complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10016441
displayName	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion
eventOf	[Pathway:R-MMU-429958] mRNA decay by 3' to 5' exoribonuclease - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-429961] DCPS scavenges the 7-methylguanosine cap of mRNA - Mus musculus
inferredFrom	[Reaction:R-HSA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [OtherEntity:R-ALL-429974] mature mRNA (eukaryotic, capped and deadenylated) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [OtherEntity:R-ALL-429926] capped oligoribonucleotide [cytosol] [SimpleEntity:R-ALL-109395] CMP [cytosol] [SimpleEntity:R-ALL-113578] GMP [cytosol] [SimpleEntity:R-ALL-109402] UMP [cytosol]
precedingEvent	[Reaction:R-MMU-429992] PARN deadenylates mRNA - Mus musculus [Reaction:R-MMU-429955] CCR4-NOT complex deadenylates mRNA - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-430028
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-429958] mRNA decay by 3' to 5' exoribonuclease
(precedingEvent)	[Reaction:R-MMU-429961] DCPS scavenges the 7-methylguanosine cap of mRNA
(inferredTo)	[Reaction:R-HSA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion

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