Reactome | GEFs activate RhoA,B,C

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GEFs activate RhoA,B,C Show undefined attributes

catalystActivity	[CatalystActivity:10005909] guanyl-nucleotide exchange factor activity of GEFs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10014620
displayName	GEFs activate RhoA,B,C
eventOf	[Pathway:R-MMU-416482] G alpha (12/13) signalling events - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-419049] ROCK activation by RHO - Mus musculus
inferredFrom	[Reaction:R-HSA-419166] GEFs activate RhoA,B,C - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-419164] RhoA,B,C:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GEFs activate RhoA,B,C
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-5666175] RhoA,B,C:GTP [plasma membrane]
precedingEvent	[Reaction:R-MMU-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Mus musculus [Reaction:R-MMU-398184] LARG activation by G alpha 12/13 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-419166
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-416482] G alpha (12/13) signalling events
(precedingEvent)	[Reaction:R-MMU-419049] ROCK activation by RHO
(inferredTo)	[Reaction:R-HSA-419166] GEFs activate RhoA,B,C