Reactome | G alpha (12/13) signalling events

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G alpha (12/13) signalling events Show undefined attributes

compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099029
displayName	G alpha (12/13) signalling events
eventOf	[Pathway:R-MMU-388396] GPCR downstream signalling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Mus musculus [Reaction:R-MMU-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Mus musculus [Reaction:R-MMU-751019] The Ligand:GPCR:G12/13 complex dissociates - Mus musculus [Reaction:R-MMU-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Mus musculus [Reaction:R-MMU-114544] p115-RhoGEF activation of RHOA - Mus musculus [Reaction:R-MMU-419166] GEFs activate RhoA,B,C - Mus musculus [Reaction:R-MMU-419049] ROCK activation by RHO - Mus musculus [Reaction:R-MMU-9680443] ROCK1,2 bind ROCKi - Mus musculus [Reaction:R-MMU-398184] LARG activation by G alpha 12/13 - Mus musculus [Reaction:R-MMU-398185] LARG binds plexin B1 - Mus musculus [Reaction:R-MMU-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Mus musculus [Reaction:R-MMU-751039] Inactive G alpha (12/13) reassociates with G beta:gamma - Mus musculus [Reaction:R-MMU-8964274] G alpha (12) binds BTK - Mus musculus [Reaction:R-MMU-8964246] BTK in G alpha (12)-BTK complex is activated - Mus musculus [Reaction:R-MMU-8964333] G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) - Mus musculus
inferredFrom	[Pathway:R-HSA-416482] G alpha (12/13) signalling events - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	G alpha (12/13) signalling events
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-416482
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-388396] GPCR downstream signalling
(hasEncapsulatedEvent)	[Pathway:R-MMU-373076] Class A/1 (Rhodopsin-like receptors)
(inferredTo)	[Pathway:R-HSA-416482] G alpha (12/13) signalling events

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