Reactome | G beta:gamma signalling through PI3Kgamma

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G beta:gamma signalling through PI3Kgamma Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099815
displayName	G beta:gamma signalling through PI3Kgamma
eventOf	[Pathway:R-MMU-397795] G-protein beta:gamma signalling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-392295] Gbeta:gamma recruits PI3K gamma - Mus musculus [Reaction:R-MMU-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-9603279] PIP3 recruits PDK1 and AKT to the membrane - Mus musculus [Reaction:R-MMU-202692] PIP3 binds to RhoA and activates it - Mus musculus
inferredFrom	[Pathway:R-HSA-392451] G beta:gamma signalling through PI3Kgamma - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	G beta:gamma signalling through PI3Kgamma
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-392451
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-397795] G-protein beta:gamma signalling
(inferredTo)	[Pathway:R-HSA-392451] G beta:gamma signalling through PI3Kgamma

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