Reactome | MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)

Schema > Reaction > Entries

MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) Show undefined attributes

catalystActivity	[CatalystActivity:8874295] serine-type endopeptidase activity of Mbtps1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10012136
displayName	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)
eventOf	[Pathway:R-MMU-381033] ATF6 (ATF6-alpha) activates chaperones - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-420818] MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) - Mus musculus
inferredFrom	[Reaction:R-HSA-381135] MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-381000] Atf6 [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)
output	[EntityWithAccessionedSequence:R-MMU-420815] Atf6 [Golgi membrane] [EntityWithAccessionedSequence:R-MMU-420814] Atf6 [Golgi membrane]
precedingEvent	[BlackBoxEvent:R-MMU-381186] ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-381135
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-381033] ATF6 (ATF6-alpha) activates chaperones
(precedingEvent)	[Reaction:R-MMU-420818] MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)
(inferredTo)	[Reaction:R-HSA-381135] MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)

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