Reactome | ATF6 (ATF6-alpha) activates chaperones

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ATF6 (ATF6-alpha) activates chaperones Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100063
displayName	ATF6 (ATF6-alpha) activates chaperones
eventOf	[Pathway:R-MMU-381119] Unfolded Protein Response (UPR) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5673197] ATF6-mediated unfolded protein response
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-MMU-381186] ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi - Mus musculus [Reaction:R-MMU-381135] MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) - Mus musculus [Reaction:R-MMU-420818] MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) - Mus musculus [BlackBoxEvent:R-MMU-381026] ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus - Mus musculus
inferredFrom	[Pathway:R-HSA-381033] ATF6 (ATF6-alpha) activates chaperones - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	ATF6 (ATF6-alpha) activates chaperones
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-381033
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-381119] Unfolded Protein Response (UPR)
(inferredTo)	[Pathway:R-HSA-381033] ATF6 (ATF6-alpha) activates chaperones