Reactome | Hsf1 [cytosol]

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-9857081] HSF1:HSPA1A,B [cytosol] - Mus musculus [Complex:R-MMU-5324677] HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] - Mus musculus
consumedByEvent	[Reaction:R-MMU-4793911] MAPKAPK2 phosphorylates HSF1 - Mus musculus [Reaction:R-MMU-3371435] Constitutive phosphorylation by GSK3 - Mus musculus [Reaction:R-MMU-3371531] Constitutive phosphorylation by pERK1/2 - Mus musculus [Reaction:R-MMU-3371591] Trimerization of cytosolic HSF1 - Mus musculus [Reaction:R-MMU-3371591] Trimerization of cytosolic HSF1 - Mus musculus [Reaction:R-MMU-3371591] Trimerization of cytosolic HSF1 - Mus musculus [BlackBoxEvent:R-MMU-9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization - Mus musculus [BlackBoxEvent:R-MMU-9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization - Mus musculus [BlackBoxEvent:R-MMU-9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10048936
displayName	Hsf1 [cytosol]
endCoordinate	529
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-3371452] HSF1 [cytosol] - Homo sapiens
maxDepth	1
name	Hsf1 HSF1 P38532
producedByEvent	[Reaction:R-MMU-5324632] Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates - Mus musculus [Reaction:R-MMU-3371586] Dissociation of cytosolic HSF1:HSP90 complex - Mus musculus [Reaction:R-MMU-9857076] Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:P38532] UniProt:P38532 Hsf1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-3371452
startCoordinate	1

(input)	[Reaction:R-MMU-4793911] MAPKAPK2 phosphorylates HSF1 [Reaction:R-MMU-3371435] Constitutive phosphorylation by GSK3 [Reaction:R-MMU-3371531] Constitutive phosphorylation by pERK1/2 [Reaction:R-MMU-3371591] Trimerization of cytosolic HSF1 [BlackBoxEvent:R-MMU-9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization
(output)	[Reaction:R-MMU-5324632] Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates [Reaction:R-MMU-3371586] Dissociation of cytosolic HSF1:HSP90 complex [Reaction:R-MMU-9857076] Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1
(hasComponent)	[Complex:R-MMU-5324677] HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] [Complex:R-MMU-4793919] HSF1:HSP90:PTGES3 [cytosol] [Complex:R-MMU-9857081] HSF1:HSPA1A,B [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-3371452] HSF1 [cytosol]

Hsf1 [cytosol] Show undefined attributes

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