Reactome | WNT ligand biogenesis and trafficking

Schema > Pathway > Entries

WNT ligand biogenesis and trafficking Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101013
displayName	WNT ligand biogenesis and trafficking
eventOf	[Pathway:R-MMU-195721] Signaling by WNT - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-MMU-3247837] WNT ligands traffic to the Golgi - Mus musculus [Reaction:R-MMU-3247840] WLS binds WNT ligands in the Golgi - Mus musculus [BlackBoxEvent:R-MMU-3247844] WNT ligands traffic to the plasma membrane - Mus musculus [BlackBoxEvent:R-MMU-3781943] WLS:WNT complex is internalized for maturation into exosomes - Mus musculus [BlackBoxEvent:R-MMU-3781941] WNTs are secreted in exosomes - Mus musculus [Reaction:R-MMU-3247843] secretion of WNT ligands - Mus musculus [BlackBoxEvent:R-MMU-3247847] WLS is endocytosed to the early endosome - Mus musculus [Reaction:R-MMU-3247839] Retromer associates with WLS - Mus musculus [BlackBoxEvent:R-MMU-3247836] Retromer recycles WLS to the Golgi - Mus musculus [BlackBoxEvent:R-MMU-3247849] WLS dissociates from retromer - Mus musculus
inferredFrom	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	WNT ligand biogenesis and trafficking
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-3238698
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-195721] Signaling by WNT
(inferredTo)	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking
(hasEncapsulatedEvent)	[Pathway:R-MMU-3858494] Beta-catenin independent WNT signaling [Pathway:R-MMU-201681] TCF dependent signaling in response to WNT

© 2026 Reactome

Cite Us!