Reactome | TCF dependent signaling in response to WNT

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TCF dependent signaling in response to WNT Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:7660] nucleoplasm
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9977036
displayName	TCF dependent signaling in response to WNT
eventOf	[Pathway:R-MMU-195721] Signaling by WNT - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-MMU-201688] WNT mediated activation of DVL - Mus musculus [Pathway:R-MMU-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Mus musculus [BlackBoxEvent:R-MMU-201669] Beta-catenin translocates to the nucleus - Mus musculus [Pathway:R-MMU-201722] Formation of the beta-catenin:TCF transactivating complex - Mus musculus [Pathway:R-MMU-3769402] Deactivation of the beta-catenin transactivating complex - Mus musculus [Pathway:R-MMU-4641258] Degradation of DVL - Mus musculus [Pathway:R-MMU-4641257] Degradation of AXIN - Mus musculus [Reaction:R-MMU-3640872] USP34 deubiquitinates AXIN1,AXIN2 - Mus musculus [Pathway:R-MMU-4641263] Regulation of FZD by ubiquitination - Mus musculus [Pathway:R-MMU-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists - Mus musculus [Reaction:R-MMU-5323545] Canonical WNT signaling through the atypical receptor RYK - Mus musculus
inferredFrom	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
isInDisease	false
isInferred	true
name	TCF dependent signaling in response to WNT
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-201681
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-MMU-9772755] Formation of WDR5-containing histone-modifying complexes [Pathway:R-MMU-3858494] Beta-catenin independent WNT signaling
(hasEvent)	[Pathway:R-MMU-195721] Signaling by WNT
(inferredTo)	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT

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