Reactome | MMADHC targets transport of cytosolic cob(II)alamin to mitochondria

Schema > Reaction > Entries

MMADHC targets transport of cytosolic cob(II)alamin to mitochondria Show undefined attributes

catalystActivity	[CatalystActivity:10047382] molecular carrier activity of MMACHC:MMADHC:cob(II)alamin [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10047384
displayName	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria
eventOf	[Pathway:R-MMU-9759218] Cobalamin (Cbl) metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-3159253] MMAB adenosylates cob(I)alamin - Mus musculus
inferredFrom	[Reaction:R-HSA-3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria - Homo sapiens
input	[Complex:R-MMU-3149533] MMACHC:MMADHC:cob(II)alamin [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria MMADHC targets cytosolic cob(II)alamin for entry to mitochondria
output	[SimpleEntity:R-ALL-3149564] cob(II)alamin [mitochondrial matrix] [EntityWithAccessionedSequence:R-MMU-2980949] MMACHC [cytosol] [EntityWithAccessionedSequence:R-MMU-3149529] Mmadhc [cytosol]
precedingEvent	[Reaction:R-MMU-3149494] MMACHC:cob(II)alamin binds MMADHC - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-3149563
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[Reaction:R-MMU-3159253] MMAB adenosylates cob(I)alamin
(inferredTo)	[Reaction:R-HSA-3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria

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