Reactome | ABCC1 transports cytosolic RCbl to extracellular region

Schema > Reaction > Entries

ABCC1 transports cytosolic RCbl to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10047175] ABC-type vitamin B12 transporter activity of ABCC1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10047177
displayName	ABCC1 transports cytosolic RCbl to extracellular region
eventOf	[Pathway:R-MMU-9758890] Transport of RCbl within the body - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-3000074] TCN2 binds RCbl in the circulation - Mus musculus
inferredFrom	[Reaction:R-HSA-3095901] ABCC1 transports cytosolic RCbl to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-9759394] RCbl [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCC1 transports cytosolic RCbl to extracellular region an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-9759382] RCbl [extracellular region]
precedingEvent	[Reaction:R-MMU-5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-3095901
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9758890] Transport of RCbl within the body
(precedingEvent)	[Reaction:R-MMU-3000074] TCN2 binds RCbl in the circulation
(inferredTo)	[Reaction:R-HSA-3095901] ABCC1 transports cytosolic RCbl to extracellular region

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