Reactome | Autophosphorylation and activation of Mekk1

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Autophosphorylation and activation of Mekk1 Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
catalystActivity	[CatalystActivity:2730845] MAP kinase kinase activity of Mekk1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643366] MAP kinase kinase activity of Mekk1 [cytosol] Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730880
displayName	Autophosphorylation and activation of Mekk1
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-MMU-933457] Mekk1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2685450] Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain [LiteratureReference:2685230] Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation and activation of Mekk1
orthologousEvent	[Reaction:R-HSA-2730887] Autophosphorylation and activation of MEKK1 - Homo sapiens
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-2685598] p-T1381,T1393-Mekk1 [cytosol]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2730880
summation	[Summation:2685541] FCERI aggregation has been shown to activate JNK as well as ...

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