Reactome | Autophosphorylation and activation of Mekk1

Autophosphorylation and activation of Mekk1

Stable Identifier

R-MMU-2730880

Type

Reaction [transition]

Species

Mus musculus

Compartment

cytosol

ReviewStatus

5/5

General

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Autophosphorylation and activation of Mekk1

FCERI aggregation has been shown to activate JNK as well as protein kinases upstream of JNK, such as MEKK1 (Mitogen-activated protein kinase/ERK Kinase Kinase-1) and JNK kinase (JNKK). PAK has been shown to be the upstream kinase involved in the activation of MEKK1, however no direct phosphorylation of MEKK1 by PAK is observed. Two threonine residues at positions 1400 and 1412 (analogous to 1381 and 1393 in mouse) in the activation loop of MEKK1 between the kinase subdomains VII and VIII are essential for its catalytic activity. The catalytic domain of MEKK1 is able to autophosphorylate these residues, enhancing its own activity.

Literature References

PubMed ID	Title	Journal	Year
9065412	Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C Siow, YL, Kalmar, GB, Sanghera, JS, Tai, G, Oh, SS, Pelech, SL	J. Biol. Chem.	1997
9078260	Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain Deak, JC, Templeton, DJ	Biochem. J.	1997

Participants

Input

Output

Catalyst Activity

MAP kinase kinase activity of Mekk1 [cytosol]

Physical Entity

Mekk1 [cytosol] (Mus musculus)

Activity

MAP kinase kinase activity (GO:0004708)

Orthologous Events

Autophosphorylation and activation of MEKK1 (Homo sapiens)

Authored

Niarakis, A (2012-12-21)

Reviewed

Roncagalli, R (2013-02-13)

Created

Garapati, P V (2012-12-05)

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