Reactome | Formation of MHC II alpha beta heterodimer

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Formation of MHC II alpha beta heterodimer Show undefined attributes

category	binding
compartment	[Compartment:5263265] lumenal side of endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10043742
displayName	Formation of MHC II alpha beta heterodimer
eventOf	[Pathway:R-MMU-2132295] MHC class II antigen presentation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Mus musculus [Reaction:R-MMU-2213241] Formation of nonameric complex - Mus musculus
inferredFrom	[Reaction:R-HSA-2213239] Formation of MHC II alpha beta heterodimer - Homo sapiens
input	[DefinedSet:R-MMU-2130718] HLA II alpha chain [lumenal side of endoplasmic reticulum membrane] [DefinedSet:R-MMU-2130672] HLA II beta chain [lumenal side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of MHC II alpha beta heterodimer
output	[Complex:R-MMU-2213186] MHC II alpha beta heterodimer [lumenal side of endoplasmic reticulum membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2213239
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-MMU-2213241] Formation of nonameric complex [Reaction:R-MMU-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer
(inferredTo)	[Reaction:R-HSA-2213239] Formation of MHC II alpha beta heterodimer