Reactome | MHC class II antigen presentation

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MHC class II antigen presentation Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100867
displayName	MHC class II antigen presentation
eventOf	[Pathway:R-MMU-1280218] Adaptive Immune System - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:14664] antigen processing and presentation of exogenous peptide antigen via MHC class II
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-2213239] Formation of MHC II alpha beta heterodimer - Mus musculus [Reaction:R-MMU-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Mus musculus [Reaction:R-MMU-2213241] Formation of nonameric complex - Mus musculus [Reaction:R-MMU-8951500] Dissociation of CANX from nonameric complex - Mus musculus [Reaction:R-MMU-2130731] Formation of COPII vesicle - Mus musculus [Reaction:R-MMU-2213243] Fusion of COPII vesicle with Golgi complex - Mus musculus [BlackBoxEvent:R-MMU-2130393] Transport of MHC II:Ii complex along Golgi to TGN - Mus musculus [BlackBoxEvent:R-MMU-2130619] TGN-lysosomal vesicle coat assembly - Mus musculus [Reaction:R-MMU-8951498] Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex - Mus musculus [Reaction:R-MMU-2130641] Translocation of TGN-lysosome vesicle to lysosome - Mus musculus [Reaction:R-MMU-2213236] TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome - Mus musculus [BlackBoxEvent:R-MMU-2130378] Transport of MHC II:Ii complex to plasma membrane - Mus musculus [BlackBoxEvent:R-MMU-2130500] Insertion of MHC II:Ii complex in to the plasma membrane - Mus musculus [Reaction:R-MMU-2130640] Recruitment of clathrin coated vesicle by Ii - Mus musculus [BlackBoxEvent:R-MMU-2130725] Internalization of MHC II:Ii clathrin coated vesicle - Mus musculus [Reaction:R-MMU-2130486] Uncoating of clathrin-coated vesicles and fusion with endosomes - Mus musculus [BlackBoxEvent:R-MMU-2213235] Trafficking of nonameric complex in the endocytic pathway - Mus musculus [Reaction:R-MMU-2130336] Initial proteolyis of Ii by aspartic proteases to lip22 - Mus musculus [Reaction:R-MMU-2130504] Cleavage of lip22 to lip10 - Mus musculus [Reaction:R-MMU-2130349] Generation of CLIP from lip10 - Mus musculus [Reaction:R-MMU-2213246] Disassociation of CLIP from MHC II - Mus musculus [Reaction:R-MMU-2213240] Reduction of disulphide bonds in MHC II antigens - Mus musculus [Reaction:R-MMU-2130706] MHC class II antigen processing - Mus musculus [Reaction:R-MMU-2213244] Loading of antigenic peptides - Mus musculus [BlackBoxEvent:R-MMU-2213248] Transport of antigen loaded MHC II molecules to surface - Mus musculus [Reaction:R-MMU-8856157] LAG3 (CD233) binds MHC II - Mus musculus
inferredFrom	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MHC class II antigen presentation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-2132295
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1280218] Adaptive Immune System
(inferredTo)	[Pathway:R-HSA-2132295] MHC class II antigen presentation

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