Reactome | CYP4F2, 4F3 20-hydroxylate LTB4

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CYP4F2, 4F3 20-hydroxylate LTB4 Show undefined attributes

catalystActivity	[CatalystActivity:10006768] leukotriene-B4 20-monooxygenase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10006770
displayName	CYP4F2, 4F3 20-hydroxylate LTB4
eventOf	[Pathway:R-MMU-211979] Eicosanoids - Mus musculus [Pathway:R-MMU-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 - Mus musculus
inferredFrom	[Reaction:R-HSA-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-266056] LTB4 [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP4F2, 4F3 20-hydroxylate LTB4 leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it
output	[SimpleEntity:R-ALL-2161636] 20OH-LTB4 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-MMU-266072] LTA4 is hydolysed to LTB4 by LTA4H - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-211873
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Pathway:R-MMU-211979] Eicosanoids
(precedingEvent)	[Reaction:R-MMU-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
(inferredTo)	[Reaction:R-HSA-211873] CYP4F2, 4F3 20-hydroxylate LTB4

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