Reactome | NADE modulates death signalling

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NADE modulates death signalling Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099655
displayName	NADE modulates death signalling
eventOf	[Pathway:R-MMU-204998] Cell death signalling via NRAGE, NRIF and NADE - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133386] regulation of apoptotic signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-193650] p75NTR binds to NADE - Mus musculus [Reaction:R-MMU-205117] p75NTR:NADE promotes caspase2/3 activation - Mus musculus [Reaction:R-MMU-204981] 14-3-3epsilon attentuates NADE-related apoptosis - Mus musculus
inferredFrom	[Pathway:R-HSA-205025] NADE modulates death signalling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NADE modulates death signalling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-205025
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-204998] Cell death signalling via NRAGE, NRIF and NADE
(inferredTo)	[Pathway:R-HSA-205025] NADE modulates death signalling

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