Reactome | 14-3-3epsilon attentuates NADE-related apoptosis

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14-3-3epsilon attentuates NADE-related apoptosis Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10005728
displayName	14-3-3epsilon attentuates NADE-related apoptosis
eventOf	[Pathway:R-MMU-205025] NADE modulates death signalling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:422917] negative regulation of endopeptidase activity
inferredFrom	[Reaction:R-HSA-204981] 14-3-3epsilon attentuates NADE-related apoptosis - Homo sapiens
input	[Complex:R-MMU-2262707] 14-3-3 epsilon dimer [cytosol] [Complex:R-MMU-204978] NGF:p75NTR:NADE [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	14-3-3epsilon attentuates NADE-related apoptosis
output	[Complex:R-MMU-205018] NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane]
precedingEvent	[Reaction:R-MMU-205117] p75NTR:NADE promotes caspase2/3 activation - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-204981
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-205025] NADE modulates death signalling
(inferredTo)	[Reaction:R-HSA-204981] 14-3-3epsilon attentuates NADE-related apoptosis

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