Reactome | beta-NGF homodimer [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-MMU-205123] mature NGF homodimer:p75NTR [plasma membrane] - Mus musculus [Complex:R-MMU-194506] RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-193653] NGF homodimer binds to p75NTR - Mus musculus [Reaction:R-MMU-166542] beta-NGF dimer binds to TrkA receptor - Mus musculus [Reaction:R-MMU-193646] NGF binding to p75NTR inactivates RHOA - Mus musculus
created	[InstanceEdit:198310] 2007-07-10 08:01:55
dbId	198272
displayName	beta-NGF homodimer [extracellular region]
hasComponent	2 × [EntityWithAccessionedSequence:R-MMU-181839] beta-NGF [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-187031] mature beta-NGF homodimer [extracellular region] - Homo sapiens [Complex:R-HSA-167057] beta-NGF homodimer [extracellular region] - Homo sapiens
maxDepth	2
name	beta-NGF homodimer
producedByEvent	[Reaction:R-MMU-187035] Pro-beta-NGF and mature beta-NGF are secreted - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-198272

(input)	[Reaction:R-MMU-193646] NGF binding to p75NTR inactivates RHOA [Reaction:R-MMU-193653] NGF homodimer binds to p75NTR [Reaction:R-MMU-166542] beta-NGF dimer binds to TrkA receptor
(hasComponent)	[Complex:R-MMU-194506] RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] [Complex:R-MMU-205123] mature NGF homodimer:p75NTR [plasma membrane] [Complex:R-MMU-198306] Activated NTRK-1:Phospho-IRS1/2 [plasma membrane] [Complex:R-MMU-198287] Activated NTRK-1:IRS1/2 [plasma membrane] [Complex:R-MMU-198286] Activated NTRK-1 [plasma membrane] [Complex:R-MMU-166537] beta-NGF dimer:TrkA receptor [plasma membrane] [Complex:R-MMU-166540] Activated TrkA receptor complex [plasma membrane] [Complex:R-MMU-198299] Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane]
(output)	[Reaction:R-MMU-187035] Pro-beta-NGF and mature beta-NGF are secreted
(inferredTo)	[Complex:R-HSA-187031] mature beta-NGF homodimer [extracellular region] [Complex:R-HSA-167057] beta-NGF homodimer [extracellular region]