Reactome | NGF binding to p75NTR inactivates RHOA

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10001632
displayName	NGF binding to p75NTR inactivates RHOA
eventOf	[Pathway:R-MMU-209563] Axonal growth stimulation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193646] NGF binding to p75NTR inactivates RHOA - Homo sapiens
input	[Complex:R-MMU-198272] beta-NGF homodimer [extracellular region] [Complex:R-MMU-194466] RHOA:GDP:ARHGDIA:NGFR [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NGF binding to p75NTR inactivates RHOA
output	[Complex:R-MMU-194506] RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-193646
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-209563] Axonal growth stimulation
(inferredTo)	[Reaction:R-HSA-193646] NGF binding to p75NTR inactivates RHOA

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