Reactome | Pregn-5-ene-3,20-dione isomerizes to progesterone

Schema > Reaction > Entries

Pregn-5-ene-3,20-dione isomerizes to progesterone Show undefined attributes

catalystActivity	[CatalystActivity:10001454] steroid Delta-isomerase activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10001469
displayName	Pregn-5-ene-3,20-dione isomerizes to progesterone
eventOf	[Pathway:R-MMU-193993] Mineralocorticoid biosynthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-193964] CYP21A2 21-hydroxylates PROG - Mus musculus [Reaction:R-MMU-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - Mus musculus
inferredFrom	[Reaction:R-HSA-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Homo sapiens
input	[SimpleEntity:R-ALL-196344] pregn-5-ene-3,20-dione [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Pregn-5-ene-3,20-dione isomerizes to progesterone
output	[SimpleEntity:R-ALL-193055] P4 [cytosol]
precedingEvent	[Reaction:R-MMU-196350] Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione - Mus musculus
regulatedBy	[PositiveRegulation:10001470] Positive regulation by 'glyco-Lutropin [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-193052
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-193993] Mineralocorticoid biosynthesis
(precedingEvent)	[Reaction:R-MMU-193964] CYP21A2 21-hydroxylates PROG [Reaction:R-MMU-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG
(inferredTo)	[Reaction:R-HSA-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone

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